Abstract:

Introduction: aneurysms of splenic arteries have a fairly high prevalence in relation to the total number of all visceral aneurysms. According to modern clinical guidelines, both symptomatic and asymptomatic aneurysms are subject to treatment. Recently, the priority direction in treatment of visceral aneurysms is endovascular surgery, which is characterized by minimal invasiveness and high efficiency, which makes it possible to consider transcatheter endovascular embolization of splenic artery aneurysms as the preferred method of treatment.

Aim: was to estimate the role and possibilities of endovascular methods of treatment in a patient with a false aneurysm of splenic artery (ASA) formed after pancreatic necrosis and complicated by gastrointestinal bleeding.

Materials and methods: a case report of transcatheter embolization of splenic artery aneurysm using the «front-to-back-door» technique using coils and telescopic system, is presented.

Results: patient was discharged on the 3rd day after embolization. The postoperative period proceeded calmly, there was no abdominal pain, indicators of clinical and biochemical blood tests were within acceptable limits.

Conclusions: studies devoted to treatment of giant aneurysms of splenic artery are not described in the modern literature, there are only few reports. Treatment of this type of ASA can lead to an increase in the cost of procedure, but minimal invasiveness, technical success, almost no deaths and early activation of patients make it possible to consider transcatheter endovascular embolization as the only possible method of treatment.

References

1.     Chaer RA, Abularrage CJ, Coleman DM, et al. The Society for Vascular Surgery clinical practice guidelines on the management of visceral aneurysms. J Vasc Surg. 2020; 72: 3-39.

https://doi.org/10.1016/j.jvs.2020.01.039

2.     Wang W, Chang H, Liu B, et al. Long-term outcomes of elective transcatheter dense coil embolization for splenic artery aneurysms: a two-center experience. J Int Med Res. 2020; 48: 300060519873256.

https://doi.org/10.1177/0300060519873256

3.     Musselwhite CC, Mitta M, Sternberg M. Splenic Artery Pseudoaneurysm. J Emerg Med. 2020; 58: 231-232.

https://doi.org/10.1016/j.jemermed.2020.02.014

4.     Rhusheet P, Mark G. Splenic artery pseudoaneurysm with hemosuccus pancreaticus requiring multimodal treatment. J. Vasc. Surg. 2019; 69: 592-595.

https://doi.org/10.1016/j.jvs.2018.06.198

5.     Venturini M, Piacentino F, Coppola A, et al. Visceral Artery Aneurysms Embolization and Other Interventional Options: State of the Art and New Perspectives. J Clin Med. 2021; 10: 2520.

https://doi.org/10.3390/jcm10112520

6.     Hemp JH, Sabri SS. Endovascular management of visceral arterial aneurysms. Tech. Vasc. Interv. Radiol. 2015; 18: 14-23.

https://doi.org/10.1053/j.tvir.2014.12.003

7.     Regus S, Lang W. Management of true visceral artery aneurysms in 31 cases. J. Visc. Surg. 2016; 153: 347-352.

https://doi.org/10.1016/j.jviscsurg.2016.03.008

8.     Kok HK, Asadi H, Sheehan M, et al. Systematic review and single center experience for endovascular management of visceral and renal artery aneurysms. J. Vasc. Interv. Radiol. 2016; 27: 1630-1641.

https://doi.org/10.1016/j.jvir.2016.07.030

9.     Gorsi U, Agarwal V, Nair V, et al. Endovascular and percutaneous transabdominal embolisation of pseudoaneurysms in pancreatitis: An experience from a tertiary-care referral centre. Clin. Radiol. 2021; 76(314): 17-23.

https://doi.org/10.1016/j.crad.2020.12.016

10.   Barrionuevo P, Malas MB, Nejim B, et al. A systematic review and meta-analysis of the management of visceral artery aneurysms. J. Vasc. Surg. 2020; 72: 40-45.

https://doi.org/10.1016/j.jvs.2020.05.018

11.   Vemireddy LP, Majlesi D, Prasad S, et al. Early Thrombosis of Splenic Artery Stent Graft. Cureus. 2021; 13: 16285.

https://doi.org/10.7759/cureus.16285

12.   Kapranov MS, Kulikovskiy VF, Karpachev AA, et al. A Case Report of Successful Endovascular Treatment of «Sentinel Bleeding» in Patient with Adverse Anatomy. EJMCM. 2020; 7(2): 146-150.

https://doi.org/10.31838/ejmcm.07.02.24

13.   Саховский С.А., Абугов С.А., Вартанян Э.Л. и др. Эндоваскулярная коррекция структурной патологии клапанов и аорты у реципиентов сердца. Эндоваскулярная хирургия. 2021; 8(1): 53-9.

Sakhovskii SA, Abugov SA, Vartanyan EL, et al. Transcatheter correction of structural valve and aortic diseases in heart recipients. Endovaskulyarnaya khirurgiya. 2021; 8(1): 53-9 [In Russ].

https://doi.org/10.24183/2409-4080-2021-8-1-53-59

14.   Tipaldi MA, Krokidis M, Orgera G, et al. Endovascular management of giant visceral artery aneurysms. Sci Rep. 2021; 11: 700.

https://doi.org/10.1038/s41598-020-80150-2

Abstract:

Introduction: treatment of splenic artery aneurysms is a complex and urgent task of modern surgery. With the development of endovascular techniques, it became possible to use fundamentally new minimally invasive methods for correction of this pathology, the essence of which is to exclude the aneurysm from the blood flow by embolization.

Case report: the article presents a case report of a young female patient without previous anamnesis, during regular examination, in which ultrasound examination, subsequent CT examination and angiography revealed saccular aneurysm of the proximal third of the splenic artery sized 22?24 mm.

Patient underwent successful endovascular embolization of aneurysm with microcoils and Onyx adhesive composition using balloon assistance performed through the transradial vascular access.

Conclusion: world experience and presented case report indicate high efficiency and relative safety of endovascular embolization of splenic artery aneurysms even under the condition of pathological vessel tortuosity, which significantly complicates the intervention, and also demonstrate the advantages of using transradial access in such anatomically difficult situations.

References

1.     Pitton MB, Dappa E, Jungmann F, et al. Visceral artery aneurysms: Incidence, management, and outcome analysis in a tertiary care center over one decade. Eur. Radiol. 2015; 25: 2004-2014.

2.     Kassem MM, Gonzalez L. Splenic Artery Aneurysm. StatPearls Publishing. 2021. Available from:

https://www.ncbi.nlm.nih.gov/books/NBK430849/

3.     Mesbahi M, Zouaghi A, Zaafouri H, et al. Surgical management of splenic artery aneurysm. Ann Med Surg (Lond). 2021; 69: 102712.

4.     Lakin RO, Bena JF, Sarac TP, et al. The contemporary management of splenic artery aneurysms. Journal of Vascular Surgery. 2011; 53: 958-965.

5.     Veluppillai C, Perreve S, de Kerviler B, Ducarme G. Splenic arterial aneurysm and pregnancy: A review. Presse Med. 2015; 44(10): 991-4.

6.     T?treau R, Beji H, Henry L, et al. Arterial splanchnic aneurysms: Presentation, treatment and outcome in 112 patients. Diagn. Interv. Imaging. 2016; 97: 81-90.

7.     Patel A, Weintraub JL, Nowakowski FS, et al. Single-center experience with elective transcatheter coil embolization of splenic artery aneurysms: technique and midterm follow-up. J. Vasc. Interv. Radiol. 2012; 23: 893-899.

8.     Hogendoorn W, Lavida A, Hunink MG, et al. Open repair, endovascular repair, and conservative management of true splenic artery aneurysms. J. Vasc. Surg. 2014; 60: 1667-1676.

9.     Reed NR, Oderich GS, Manunga J, et al. Feasibility of endovascular repair of splenic artery aneurysms using stent grafts. J Vasc Surg. 2015; 62(6): 1504-10.

10.   Posham R, Biederman DM, Patel RS, et al. Transradial approach for noncoronary interventions: a single-center review of safety and feasibility in the first 1,500 cases. J. Vasc. Interv. Radiol. 2015; 27(2): 159-166.

Abstract:

Aneurism of the splenic artery is a rare, but potentially life-threatening condition. In the majority of patients with an aneurism of unpaired visceral arteries the endovascular procedure is a treatment of choice. Of them stent graft implantation is considered as the most promising method. However, until recent only balloon-dilated stent grafts were used. Due to a rigid delivering system this type of grafts cannot be implanted in distal branches of visceral arteries, that is significant limitation of this technique. Technological advances and developing of low-profile soft self-expanding grafts allow overcoming this limitation. New type of grafts opens the possibility to exclude aneurisms even in conditions of marked vessel tortuosity and complex vascular anatomy

Conclusion: stent-graft implantation is an effective and safe method of treatment of splenic artery false aneurisms. This method allows to reliably exclude an aneurism from the circulation and is not associated with increased risk of thrombotic complications. Modern low-profile soft self-expanding grafts open new possibility in treatment of visceral arteries aneurisms even in conditions of marked vessel tortuosity and complex vascular anatomy.

References

1.    Pokrovskij A.V. Zabolevanija aorty i ee vetvej. M. Medicina. 1979; 324 [In Russ].

2.    Nosher J.L., Chung J., Brevetti L.S. et al. Visceral and renal artery aneurysms: a pictorial essay on endovascular therapy. RadioGraphics. 2006; 26: 1687-1704.

3.    Hossain A., Reis E.D., Dave S.P. et al. Visceral artery aneurysms: experience in a tertiary-care center. Am Surgr. 2001; 67(5): 432-437.

4.    Stanley J.C., Fry W.J. Pathogenesis and clinical significance of splenic artery aneurysms. Surgery. 1974; 76: 898-899.

5.    Messina L.M., Shanley C.J. Visceral artery aneurysms. Surg. Clin. North. Am. 1997; 77: 425-442.

6.    Meng WC.S., Chan M., Lau W.Y., Li A.K.C. Splanchnic aneurysms. H. K M. J 1995; 1(2): 173-177.

7.    Lai R., Mallery S. Primary splenic artery aneurysm diagnosed by EUS. Visible Human Journal of Endosonography. 2002; 4(1): 2-3.

8.    Kemmeter P., Bonnell B., VanderKolk W. et al. Percutaneous thrombin injection of splanchnic artery aneurysms: two case reports. J. Vasc. Interv. Radiol. 2000; 11(4): 469-472.

9.    Kasirajan K., Greenberg R.K., Clair D., Ouriel K. Endovascular management of visceral artery aneurysm. J. Endovasc. Ther. 2001; 8: 150-155.

10.  Janzen R.M., Simpson W.T. Visceral artery aneurysm. C. J. S. - 2004; 43(4): 301-302.

11.  Ikeda O., Tamura Y., Nakasone Y. et al. Coil embolization of pancreaticoduodenal artery aneurysms associated with coeliac artery stenosis: report of three cases. Cardiovasc. Intern Radiol. 2007; 30: 504-507.

12.  Chino O., Kijama H., Shibuya M. et al. A case report: spontaneous rupture of dissecting aneurysm of the middle colic artery. Tokai. J. Exp. Clin. Med. 2004; 29(4): 155-158.

13.  Babadzhanov B.R., Husainov B.R., Juldashev G.Ju. Anevrizma selezenochnoj arterii kak prichina segmentarnoj vnepechenochnoj portal'noj gipertenzii [Splenic artery aneurism as a cause of anhepatic segmentary portal hypertension]. Klinicheskaja hirurgija. 1989; 9: 62-63 [In Russ].

14.  Gavrilenko A.V. Hirurgicheskoe lechenie hronicheskoj abdominal'noj ishemii: Dis. dokt. med. nauk. M., 1990 [In Russ].

15.  Lishenko A.N., Ermakov E.A., Shalaginov S.I., Gofman A.V. Razryv anevrizmy selezenochnoj arterii [Splenic artery aneurism rupture]. Hirurgija. 2005; 7: 58-59 [In Russ].

16.  Pokrovskij A.V. Klinicheskaja angiologija: Rukovodstvo v 2-h tomah. M. Medicina. 2004;2: 117-128 [In Russ].

17.  Stanley J.C., Wakefield T.W., Graham L.M. et al. Clinical importance and management of splanchnic artery aneurysms. J. Vasc. Surg. 1986; 3: 836-840.

18.  Tochii M., Ogino H., Sasaki H. et al. Successful surgical treatment for aneurysm of splenic artery with anomalous origin. Ann. Thorac. Cardiovasc. Surg. 2005; 11(5). 346-349.

19.  Wagner W.H., Allins A.D., Treiman R.L. et al. Ruptured visceral artery aneurysms. Ann. Vasc. Surg. 1997; 11(4): 342-347.

20.  Weber C.H., Pfeifer K.J., Tato F. et al. Transcatheter coil embolization of an aneurysm of the pancreatico-duodenal artery with occluded celiac trunk. Cardiovasc. Intern Radiol. 2005; 2: 259-261.

21.  Karaman K., Onat L., Sirvanci M., Olga R. Endovascular stent graft treatment in a patient with splenic artery aneurysm. Diagn. Interv. Radiol. 2005; 11: 119-121.

22.  Jibiki M., Inoue Y., Iwai T. et al. Treatment of three pancreaticoduodenal artery aneurysms associated with coeliac artery occlusion and splenic artery aneurysm: a case report and review of the literature Eur. J. Vasc. Endovasc. Surg. 2005; 29(2): 213-217.

23.  Porcu P., Marongiu G.M., Bacciu P.P. Aneurysms of the celiac artery: case report and review of the literature . J. Mal. Vasc. 2002; 27(2): 88-92.

24.  Pulcini G., D’Adda F., Lanzi S. et al. Aneurysms of the superior mesenteric artery. Ann. Ital. Chir. 2002; 73(2): 129-136.

25.  Sakai H., Urasawa K., Oyama N., Kitabatake A. Successful covering of a hepatic artery aneurysm with a coronary stent-graft. Cardiovasc. Interv. Radiol. 2004; 27: 274-277.

26.  Duncan A.A. Median arcuate ligament syndrome. Curr. Treat. Options. Cardiovasc. Med. 2008; 10(2): 112-116.

27.  Gandini R., Pipitone V., Konda D. et al. Endovascular treatment of a giant superior mesenteric artery pseudoaneurysm using a nitinol stent-graft. Cardiovasc. Interv. Radiol. 2005;1: 102-106.

28.  Grego F.G., Lepidi S., Ragazzi R. et al. Visceral artery aneurysms: a single center experience. Cardiovasc. Surg. 2003; 11(1): 19-25.

29.  Troickij A.V., Bobrovskaja A.N., Orehov PJu. i dr. Uspeshnoe chreskozhnoe jendovaskuljarnoe lechenie razryva anevrizmy bedrennoj arterii [Succesfull endovascular treatment femoral artery aneurism rupture]. Angiologija i sosudistaja hirurgija. 2005; 11(1): 53-57 [In Russ].

30.  Chen F., Kriegshauser L.S., Huettl E.A., Roberts C.C. Percutaneous thrombin injection for treatment of a splenic artery aneurysm. Radiology. 2006; 1(1): 13-16.

31.  Cope C., Zeit R. Coagulation of aneurysms by direct percutaneous thrombin injection . A.J.R 1986; 147: 383-387.

32.  Guillon R., Garcier J.M., Abergel A. et al. Management of splenic artery aneurysms and false aneurysms with endovascular treatment in 12 patients . Cardiovasc. Interv. Radiol. 2003; 26: 256-260.

33.  Jenssen G.L., Wirsching J., Pedersen G. et al. Treatment of a hepatic artery aneurysm by endovascular stent-grafting. Cardiovasc. Interv. Radiol. 2007; 30: 523-525.

34.  Hyun-Ki Y., Mats L., Petr U. et al. Stent-graft repair of a splenic artery aneurysm. Cardiovasc. Interv. Radiol. 2001; 24: 200-203.

35.  Garg A., Banait S., Babhad S. et al. Endovascular treatment of pseudoaneurysm of the common hepatic artery with intra-aneurysmal glue (N-butyl 2-cyanoacrylate) embolization. Cardiovasc. Intern Radiol. 2007; . 30: 999-1002.

36.  Gabelmann A., Gorich J., Merkle E.M. Endovascular treatment of visceral artery aneurysm J. Endovasc. Ther. 2002; 9: 38-47.

Abstract:

Purpose: to prove the safety and efficiency of minimally invasive endovascular and puncture techniques in management of splen diseases in children.

Aims: to develop standard procedures and justify the necessity of splenic artery embolization (SAE) in hemangiomas, extrahepatic portal hypertension, and idiopathic thrombocytopenic purpura (ITP). Develop standard procedures for splenic cysts treatment in pediatric practice.

Materials and methods: there were 129 children aged 3-16 years treated in Endovascular Surgery Department of Russian State Pediatric Hospital (Moscow) with the following diagnoses: hemangiomas (4 patients), hereditary hemolytic globular-cell anemia - HHGCA (41 cases), extrahepatic portal hypertension - EHPG (25 cases), ITP (24 cases), and nonparasitic cysts (35 patients).

Results: SAE is shown to be effective in treatment the diseases where splenic hyperfunctioning is seen. In HHGCA and ITP no hemolytic crises were seen, and there was no need of substitution therapy after performing the SAE procedure. In cases of EHPG splenic artery embolization is proved to reduce the esophageal varices and decrease hypersplenia symptoms. Among the advantages of endovascular approach can be named minimal operation trauma and splenic tissue preservation. The authors present an algorithm for splenic cysts treatment in pediatric practice. It was shown that laparoscopy is effective in big (over 70-80 mm) subcapsular cysts, whereas intraparenchymatous cysts fewer than 70 mm in diameter are more suitable for puncture techniques.

Conclusions: the minimally invasive techniques are shown to be safe and effective in management of splen diseases in pediatric practice. It was shown that their effectiveness is comparable to the conventional methods, meanwhile they cause much less operation trauma, reduce the hospital stay and terms of rehabilitation.

References 

1.    LokichJ., Cosstello P. Splenic embolization to prevent dose limitation of cancer chemotherapy. Am.J. Roentgenol. 1983; 140: 159-161.

2.    Spigos  D.G., Jonasson  O.  Partial  splenic embolisation in the treatment of hypersplenism. Am.J. Roentgenol. 1979; 132: 777-782.

3.    Styrt B.  Infection associated with asplenia: risk, echanism and prevention. Am. J. Med.1990; 88: 5-33.

4.    Никаноров А.Ю.  Рентгеноэндоваскулярная окклюзия в подавлении патологической функции селезенки у детей. Дис. канд.мед. наук. М. 1990.    13.

5.    Григорьева Е.Г., Апарицина К.А.  Органосохраняющая хирургия селезенки.  Новосибирск. 2001; 23-78.

6.    Дергачев А.И. Абдоминальная эхография. М. 2002; 15-25.

7.    Журило И.П., Литовка В.П., Кононученко В.П.,  Москаленко  В.З.  Непаразитарные кисты селезенки у детей. Хирургия. 1993; 8:59-61

8.    Куликов Л.К.,  Филиппов А.Г. Хирургическая тактика при непаразитарных кистах селезенки. Хирургия. 1995; 2: 62-63.

9.      Fowler   R.H.   Nonparasitic   bening   cystic tumors of the spleen. Int. Abstr. Surg. 1953; 96: 209-227.

10.    Martel M., Cheuk W. Angiomatoid Nodular Transformation (SANT). Report of 25 Cases of Distinctive Begin Splenic Lesion. J. Surg. Pathol. 2004; 28 (10): 1268-1279.

11.    Кургузов О.П., Кузнецов Н.А., Артюхина Е.Г. Непаразитарные кисты селезенки. Хирургия. 1990; 6: 130-133.

12.    Папаскуа И.З. Возможности чрескожных пункционно-дренирующих вмешательств с ультразвуковым контролем в лечении кист печени, почек и селезенки. Дис. канд. мед. наук. С-Пб. 2003.

13.    Ратнер Г.Р. Непаразитарные кисты селезенки. Вестник хирургии.1997; 5: 104-105.

14.    Шишкин К.В. Хирургическое лечение непаразитарных кист печени и селезенки. Хирургия (журнал имени Н.И. Пирогова). 2006; 10: 62-66.

15.    Маннанов А.Г. Эндоскопическая хирургия непаразитарных кист селезенки у детей. Дис. канд. мед. наук. М. 2004.

16.    Филижанко В.Н.,  Шеменева Е.Г.,  Фомин А.М. и др. Лапароскопические вмешательства при кистах печени и селезенки. Эндоскопическая хирургия. 1998; 1: 56.

17.    Bove T., Delvaux G., Van Eijkelenburg P., De Backer A., Willems G. Laparoscopic-assisted surgery of the spleen: clinical experience in expanding indications. J. Laparoendosc. Surg. 1996; 6 (4): 213-217.

18.  Bean WJ., Rodan B.A. Hepatic cysts: Treatment with alcohol. AJR. 1985; 237-241.

19.  Gresik M.V.  Pathology of the spleen. New-York. 1989; 37.

20.  Velkova K., Nedeva A. Our experience in the diagnostiks of liver and spleen hemangiomas. Plovdiv. Folia. Med. 1997; 39 (1): 85-91.

21.  Levy A.D., Abbot R.M., Abbondanso S.L. Littoral cell angioma of the splen: CT features with clinicopatologic comparison. Radiology. 2004; 230 (2): 485-490.

22.  Yano H., Imasato M., Monde T. et al. Hand-assisted   laparoscopic splenectomy for splenic vascular tumors:  report of two cases.  Surg.Laparosc. Percutan. Tech. 2003; 13 (4): 286-289.

23.  Coon W.W. Splenectomy in the threatment of hemolitic   anemia.   Arch.   Surg.   1985;   120: 625-628.